Vol. III, Issue #22
Bergen CFS Support Group Newsletter
Our guest speaker on Sunday October 18 was Tracey Gold, from The Institute of Neurological Care in Englewood Cliffs, NJ - the office of Dr. Nancy Mueller. Neurology is the diagnosis and treatment of diseases and disorders of the brain, nervous system and spinal cord through non-surgical means. Tracey discussed the challenge of breaking the cycle of chronic pain and stress to lower the pain threshold. Dr. Mueller and her staff of experienced professionals treat patients with CFS, Lyme disease, migraines, nerve and disc disorders, sleep disorders, stroke, Parkinson's and many other conditions. After careful evaluation and testing by a physician, pain can be managed using medications or alternative pain management therapies, or combinations of these methods. Dr. Nancy Mueller is a Neurologist who works closely with the specialists in her office to provide chiropractic care, acupuncture, physical therapy, and massage therapy in a coordinated and holistic approach to caring for her patients. (by Judy Machecek)
The second part of the meeting was open discussion. Members shared with the whole group and later in small clusters that spontaneously formed. As usual, we stayed well passed the stated time of .
Next weekend, the NJCFSA Fall Conference will be held. Complete details are included again for your convenience. Please consider attending. If you need a ride please contact Anne Gilmartin. She and some other members have offered rides to those wishing to attend. If you have not yet registered, please send your application and check today. Also, call Nancy Visocki (201-439-0704) to ensure you will be on the list.
Chest Online, and the URL http://www.chestjournal.org
COPYRIGHT © 2005 by the American College of Chest Physicians.
Marcel A. Baltzan, MD*, Osama Elkhouli, MD, Laura Creti, PhD, Sally Bailes, PhD, Catherine Fichten, PhD, Norman Wolkove, MD and Eva Libman, PhD
PURPOSE: Patients with chronic fatigue syndrome (CFS), as defined by Centers of Disease Control criteria, often have a potentially treatable sleep disorder. However, even when obstructive sleep apnea (OSA) is identified in these patients, improvement with treatment is not predictable. We sought to determine whether any parameters of the diagnostic or titration sleep study were associated with improvement in symptoms of CFS after a subsequent trial of home CPAP.
METHODS: We reviewed the clinical and polysomnographic (PSG) findings of 78 patients with CFS. Thirty-nine (50%) were found to have OSA and underwent a CPAP titration night. Thirty-seven pts subsequently agreed to a therapeutic CPAP trial lasting up to 6 months. They then rated their CFS symptoms as "improved" or "not-improved".
RESULTS: In the diagnostic PSG, patients with CFS who reported improvement to later CPAP had a higher mean arousal index 67.6 (70.1) vs. 26.1 (12.1) in those who did not improve (p = 0.037). The following table compares several PSG variables in patients who improved with the CPAP trial compared with those who did not. Each value represents the change between the diagnostic and CPAP titration nights (mean and standard deviation).
CONCLUSION: Patients with CFS and OSA are more likely to improve with CPAP if they have higher arousal indices in the diagnostic PSG and show improved sleep efficiency during CPAP titration. Changes in REM latency and stage 1 and 2 sleep may also predict improvement.
CLINICAL IMPLICATIONS: The above mentioned PSG variables may be clinically useful in predicting which patients with CFS and OSA are more likely to improve with CPAP use.
DISCLOSURE: Marcel Baltzan, None.
*REMINDER* - NJCFSA Conference
Please consider attending this conference. It is an opportunity to hear some of the people who work so hard on our behalf.
FEE: $30 per person (parking is free)
– Registration & Exhibits
Introduction & Welcome
CFIDS and Diastolic Cardiomyopathy
Paul Cheney, MD, PhD, Director of The Cheney Clinic in Wilmington, North Carolina and pioneering clinical researcher in field of CFS.
Educating the Child with CFIDS
Shanon McQuown, Special Education Coach and author of recently published book “Harnessing the Wind: Chronic Fatigue Syndrome and My Son.”
Break – Light Refreshments
News Update on CFS and Related Disorders
MD, FAAP, Board Certified Internist and Infectious Disease Specialist;
CFS Clinician and Researcher, Private Practice,
Questions and Answers
Research (Part 2)
Chronic fatigue gene signs found
Scientists believe they have pinpointed biological markers of chronic fatigue syndrome which could help develop a test and treatment for the condition.
CFS, or ME, makes people
feel extremely tired, and can cause weakness, headaches, and disrupted
sleep. Scientists, now based at
The scientists say their findings fit with the understanding that a virus, such as Epstein-Barr, may trigger CFS/ME, because that illness might alter how genes are expressed. CFS/ME often first appears as a flu-like illness, but does not then go away.
The researchers compared levels of gene expression in the white blood cells of 25 healthy people and 25 who had CFS using DNA chip technology. They found differences in the behavior of 35 of the 9,522 genes they analyzed. Further genetic testing showed 15 of the genes were up to four times more active in people with CFS, while one gene was less active. Several genes the team pinpointed play important roles in mitochondria, the "powerhouse" of cells.
One of the products of these genes is EIF4G1, which is involved in the protein production in mitochondria. EIF4G1 is hijacked by some viruses, so cells may compensate by increasing gene expression. The genetic differences lead to changes in how blood proteins behave which could allow the development of a blood test for CFS, the team says.
Other genes are involved in regulating the immune system or playing important roles in nerve cells. The team will now carry out further research on 1,000 CFS patients and healthy people.
Dr Jonathan Kerr who led the
research team, which is currently in the process of moving to
from BBC NEWS:
© BBC MMV
The next scheduled
meeting will be on Sunday November 20th. We will have
a discussion and provide information about the various CFS
organizations in the
This newsletter is intended for CFS patients in the area of this support group. The purpose is to share information and support. If you have questions about meetings please contact Group Leader Anne at firstname.lastname@example.org. Subscription problems: Nancy Visocki at email@example.com. Editor: Pat LaRosa at firstname.lastname@example.org.